- A white light metrology camera utilizing the CMOSIS CSI2100 in combination with Quad CoaXPress connectivity, the Adimec Q-2A750
- A high-speed, high full well capacity (2000 kel) range CMOS image sensor from CMOSIS, the CMOSIS CSI2100
- A high-speed full-field OCT microscope (Light-CT scanner) able to receive large samples and an FFOCT endoscope from LLTech
The CAReIOCA project, a European Union sponsored FP7 project, was started in early 2013 to provide pathologists and/or surgeons non-invasive optical imaging at the cellular level within the human body in real time. The optical technology used in the end system is based on Full Field Optical Coherence Tomography (FFOCT), a technique that enables volumetric image capture on semi-transparent tissue at micron resolution in 3D. The technology intends to assist in diagnosis, particularly of cancer, in skin, breast, prostate, brain etc., as well as quality control of biopsies.
In the project five parties cooperated in the development of technology, devices and clinical assessment. These parties are Adimec (Netherlands), CMOSIS (Belgium), LLTech (France), Leiden University Medical Center (LUMC, Netherlands) and Institute Goustav Roussy (France).
Clinically speaking, the FFOCT imaging diagnosis performance was thoroughly tested on head and neck cancer and breast cancer, but other interesting applications were explored as you will see at the end of this issue.
With further optimization and certification work, the new camera and the high-speed FFOCT microscope will soon be available in Adimec and LLTech product catalogues. Pre-products will already be demonstrated at Photonics West 2016 Exhibition in San Francisco in February. The clinical results will also be presented at this conference and at other biomedical congresses in 2016.
The integration of the Q-2A750 camera in the FFOCT prototypes has brought significant gains in terms of sensitivity and speed. Both systems’ sensitivity is multiplied by 3 in comparison to their performance with a conventional camera (200 kel, 150fps). The large size of the sensor also increases the unit field of view.
With such upgraded performance, the FFOCT microscope is now fast enough to enter the clinical workflow of intra- operative tissue assessment. Upcoming developments at LLTech will be based on the integration of this new camera and the fulfillment of necessary certifications to soon offer a high-speed FFOCT microscope for research first and for clinical use shortly afterwards.
The FFOCT endoscope is more in an exploration phase where users’ feedback is analyzed in order to refine the initial specifications and work on design changes. An image taken with the prototype endoscope is shown below (right) next to an image of the same sample recorded at the approximate same depth with the LLTech commercial microscope (Light-CT scanner). The sample used is a rat brain coronal slice so that axon fibers and bundles are visible longitudinally (upper area) and transversally (lower area). With the current endoscope, both sensitivity and resolution are lower than with the Light-CT scanner so that the image is less informative than the one taken with the microscope. Besides the study done at IGR on head and neck biopsies, the endoscope is tested at TIMC lab in Grenoble on two other applications: cartilage and prostate surgeries.
This project received funding from the European Union Seventh Framework Program FP7-ICT-2011-8 under grant agreement number 318729.
For more information on the CAReIOCA project, see: http://www.careioca.eu/index.php?option=com_content&view=frontpage&Itemid=1